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Brain tumors, particularly high-grade gliomas, are among the most aggressive and lethal forms of cancer. These tumors present a significant challenge due to their rapid growth, resistance to conventional therapies, and complex genetic and molecular profiles. Our research is focused on unraveling the molecular mechanisms driving these tumors, with the aim of developing novel therapeutic and diagnostic approaches that can improve patient outcomes.
Our group is primarily focused on the following research line:
Study of RNA Processing Alterations in High-Grade Gliomas for the Development of New Therapeutic and Diagnostic Strategies: We are investigating RNA processing events in high-grade gliomas by analyzing public RNA sequencing datasets (such as those from the CGGA and TCGA cohorts) as well as data generated from samples obtained through the Basque healthcare system.
In our research, RNA splicing analysis is conducted using advanced bioinformatics tools such as VAST-TOOLS and rMATS.
Our goal is to identify RNA processing alterations that can be targeted for therapeutic interventions, utilizing RNA manipulation strategies like those we are exploring in our neurodegenerative disease research. Additionally, our team is dedicated to characterizing circulating free RNA in the serum of glioma patients, aiming to develop novel diagnostic and prognostic tools that can aid in early detection and personalized treatment planning.
FUNDING
FUNDING
This research line is funded through the following projects:
Predoctoral grant to Ane Rubio (Department of Education – Basque Government. Ref. PRE_2021_1_0166)
Lab AECC LABAE211719BLAZ project
Project of the Department of Health of the Basque Government (Line Promotion of health research activity with Ref. 2021111061).
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